Condition: Glioblastoma WHO Grade IV · Sponsor: Nader Sanai
This is an open-label, multi-center, Phase 0/1 dose-escalation trial designed to enroll up to 12 total recurrent glioblastoma (rGBM) participants with confirmed MTAP loss/deletion in their archival or pretreatment biopsy tissue, who are scheduled for surgical resection. MTAP loss/deletion will be determined by next-generation sequencing (NGS). The trial will include a dose escalation design to evaluate the pharmacokinetics (PK) and safety and tolerability of BMS-986504 (MRTX1719). The trial will be composed of a Phase 0 component and an Expansion Phase 1 component. Participants with tumors demonstrating a positive PK response in the Phase 0 component of the study will be eligible to enroll into the the Phase 1 component that will include 21-day cycles of therapeutic dosing of BMS-986504.
This description comes directly from the study's public registry record.
Phase 0 Navigator · 602-406-8605 · research@ivybraintumorcenter.org
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| St. Joseph's Hospital and Medical Center | Phoenix, Arizona, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06883747