Condition: Glioma · Sponsor: Regina Elena Cancer Institute
Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopic expression of the miRNAs identified by us has a negative impact on cell viability, proliferation and apoptosis, but above all on migration and invasion.
This description comes directly from the study's public registry record.
Ana Belen Diaz, Doctor · 06-52662522 · anabelen.diaz@ifo.it
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| "Regina Elena" National Cancer Institute | Rome, Rome, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06883214