Condition: Acute Lymphoblastic Leukemia ALL · Childhood Leukemia, Acute Lymphoblastic · B Cell Acute Lymphoblastic Leukemia (B-ALL) · Sponsor: Institute of Hematology & Blood Diseases Hospital, China
CCCG-ALL2025 LR-B-ALL plan is designed based on the CCCG-ALL2020 plan. This is a clinical trial using 14 days of blinatumomab (Blina-14) as early intensification after induction therapy and 2nd Blina-14 in consolidation therapy in all newly diagnosed provisional low-risk (LR) pediatric acute lymphoblastic leukemia (ALL) patients, regardless of measurable residual diseases (MRD) status. We will compare the efficacy of chemotherapy combined with Blina-14, comparing to CAT+ intensification or historical regimens. Patients with early remission in depth will receive chemo-light late intensification and maintenance therapy afterwards. Early complete remission in depth and maintenance reduction will be determined by next-generation sequencing (Ig-NGS MRD).
This description comes directly from the study's public registry record.
Xiaofan Zhu, MD · + 86 22 23909001 · xfzhu@ihcams.ac.cn
Jingliao Zhang, MD · +86 22 23909196 · zhangjingliao@ihcams.ac.cn
Always discuss trial participation with your own doctor first.
| Anhui Medical University Second Affiliated Hospital | Hefei, Anhui, China | Not Yet Recruiting |
| Anhui Provincial Children's Hospital | Hefei, Anhui, China | Not Yet Recruiting |
| Chongqing Medical University Affiliated Children's Hospital | Chongqing, Chongqing Municipality, China | Not Yet Recruiting |
| Fujian Medical University Union Hospital | Fuzhou, Fujian, China | Not Yet Recruiting |
| Guangzhou Women and Children's Medical Center | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Nanfang Hospital, Southern Medical University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The People's Hospital of Guangxi Zhuang Autonomous Region | Nanning, Guangxi, China | Not Yet Recruiting |
| The Affiliated Hospital of Guizhou Medical University | Guiyang, Guizhou, China | Not Yet Recruiting |
| Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology | Wuhan, Hubei, China | Not Yet Recruiting |
| Union Hospital of Tongji Medical College, Huazhong University of Science and Technology | Wuhan, Hubei, China | Not Yet Recruiting |
| Wuhan Children's Hospital | Wuhan, Hubei, China | Not Yet Recruiting |
| Hunan Children's Hospital | Changsha, Hunan, China | Not Yet Recruiting |
+ 15 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06882057