Condition: Severe Hypertriglyceridemia · Sponsor: Arrowhead Pharmaceuticals
This study will evaluate the efficacy and safety of plozasiran in approximately 288 adult participants with severe hypertriglyceridemia (SHTG) and history of at least two prior acute pancreatitis (AP) events not attributed to other etiologies, with at least one occurring within the last 12 months prior to screening. Eligible participants will be randomly assigned in a double-blind manner to either receive plozasiran 25 mg by subcutaneous (SC) injection every three months (Q3M) or matching placebo. Enrolled participants will be counseled to remain on the specified low-fat diet and background medications throughout the study. Following completion of the double-blind treatment period, or if the participant has a positively adjudicated AP event (whichever occurs first), participants will transition to the 12-month Open-Label Extension (OLE) treatment period receiving plozasiran 25 mg by SC injection Q3M.
This description comes directly from the study's public registry record.
Medical Monitor · 626-304-3400 · plozasiran@arrowheadpharma.com
Always discuss trial participation with your own doctor first.
| Research Site | Los Angeles, California, United States | Recruiting |
| Clinical Research Site 4 | Santa Clarita, California, United States | Recruiting |
| Research Site | New Haven, Connecticut, United States | Recruiting |
| Clinical Research Site 6 | Springfield, Illinois, United States | Recruiting |
| Research Site | Indianapolis, Indiana, United States | Recruiting |
| Research Site | Kansas City, Kansas, United States | Recruiting |
| Research Site | Ann Arbor, Michigan, United States | Recruiting |
| Research Site | St Louis, Missouri, United States | Recruiting |
| Clinical Research Site 5 | North Platte, Nebraska, United States | Recruiting |
| Clinical Research Site 3 | Greensboro, North Carolina, United States | Recruiting |
| Research Site | Wilmington, North Carolina, United States | Recruiting |
| Clinical Research Site 7 | Philadelphia, Pennsylvania, United States | Recruiting |
+ 90 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06880770