Condition: B-Cell Non-Hodgkin Lymphoma · B-cell Acute Lymphoblastic Leukemia · Sponsor: University of Kansas Medical Center
This multicenter phase 1 trial with "3 + 3" dose escalation design seeks to examine the feasibility and safety of the administration of autologous T cells that have been modified through the introduction of chimeric antigen receptors targeting the B cell surface antigens CD19/20/22 following administration of a chemotherapy lymphodepletion regimen in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) or Non-Hodgkin's lymphoma (NHL). The overall goals of this study are to estimate maximum tolerated dose (MTD) level, establish the overall safety profile and evaluate initial efficacy of administering duo-CAR-T cell treatment in this patient population.
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| University of Kansas Cancer Center | Westwood, Kansas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06879340