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Study identifier: NCT06878417 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Cannabinoids for Osteoarthritis Pain Effectiveness Trial

Condition: Osteoarthritis of Knee · Osteoarthritis Hip  ·  Sponsor: University Health Network, Toronto

PhaseNA
Planned participants100
Who can joinAll sexes, 40 Years to 80 Years
Healthy volunteersNo

About this study

This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians. Current OA treatments often have limited effectiveness and may cause side effects. As a result, many individuals with OA turn to medical cannabis for pain relief, despite limited scientific evidence supporting its efficacy. The goal of this study is to assess the feasibility of a larger trial evaluating the effects of two cannabis compounds-CBD and THC-compared to a placebo (a look-alike substance containing no active drug) on pain interference in patients with hip and/or knee osteoarthritis. Participants will: * Take either CBD, THC, or a placebo capsule daily for 8 weeks * Complete follow-ups remotely, with no in-person clinic visits required * Maintain a diary tracking their study drug usage and any additional pain medications

This description comes directly from the study's public registry record.

Talk to the study team

Sonal Thaker  ·  1-416-340-4800  ·  sonalben.thaker@uhn.ca

Deep Grewal  ·  1-416-340-4800  ·  Deep.Grewal@uhn.ca

Always discuss trial participation with your own doctor first.

Locations (3)

University Health NetworkToronto, Ontario, CanadaRecruiting
Women's College HospitalToronto, Ontario, CanadaRecruiting
McGill University Health Centre/Montreal General HospitalMontreal, Quebec, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06878417