Condition: Stroke · Stroke (in Patients With Atrial Fibrillation) · Ischemic Stroke · Sponsor: Guri Hagberg
This study looks at whether stroke patients who take FXa inhibitors (a type of blood thinner) can safely receive clot-busting treatment (IVT). IVT is a common emergency treatment for stroke, but current guidelines say it should not be given to people who have taken FXa inhibitors in the last 48 hours. This is because doctors worry that IVT might cause dangerous bleeding in the brain. However, new research suggests that IVT might be safe for these patients. Some studies even show that stroke patients on FXa inhibitors who receive IVT do not have a higher risk of brain bleeding than other stroke patients. But because these studies were not designed as full medical trials, doctors still avoid IVT for this group. The SIFT trial will compare two groups of stroke patients who take FXa inhibitors: One group will receive IVT to see if it helps them recover better. One group will not receive IVT, which is the current standard. Doctors will check if IVT helps with recovery and if it causes any serious bleeding. If IVT is found to be safe and effective, this study could change stroke treatment guidelines and help more patients get life-saving care. Right now, some guidelines say that stroke patients on FXa inhibitors should have a blood test before getting IVT, to measure how much of the drug is in their system. But these tests are not available in most hospitals, and waiting for results could delay important treatment. The SIFT trial will not require this test before giving IVT. M…
This description comes directly from the study's public registry record.
Guri Hagberg, MD, PhD · +47 92821843 · guhagb@ous-hf.no
Kim L Schultz, MD · +47 40859583 · kimsch@ous-hf.no
Always discuss trial participation with your own doctor first.
| Dept. of Medicine, Baerum Hospital | Bærum, Gjettum, Norway | Recruiting |
| Dept of Medicine, Helse More and Romsdal Health Trust, Aalesund Hospital | Ålesund, Norway | Recruiting |
| Dept of Medicine, Haraldsplass deaconal Hospital | Bergen, Norway | Recruiting |
| Dept. Of Neurology, Haukeland University Hopsital | Bergen, Norway | Recruiting |
| Dept of Neurology, Drammen Hospital Trust | Drammen, Norway | Recruiting |
| Dept of Neurology, Ostfold Hospital Trust, Kalnes | Grålum, Norway | Recruiting |
| Dept of Neurology, Hospital of Southern Norway, SSHF | Kristiansand, Norway | Recruiting |
| Dept of Neurology, Innlandet Hospital Trust, Lillehammer | Lillehammer, Norway | Recruiting |
| Dept. of Neurology, Oslo University Hospital | Oslo, Norway | Recruiting |
| Dept of Neurology, Stavanger University Hospital | Stavanger, Norway | Recruiting |
| Dept. of Neurology, Tromso University Hospital | Tromsø, Norway | Recruiting |
| Dept. Of Medicine, St.Olav Hospital, Trondheim | Trondheim, Norway | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06878066