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Study identifier: NCT06876649 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

Condition: Chronic Lymphocytic Leukemia · Non-Hodgkin Lymphoma  ·  Sponsor: Eli Lilly and Company

PhasePhase 4
Planned participants787
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The master protocol study J2N-MC-JZNY provides a framework to enable the evaluation of the long-term safety and efficacy of pirtobrutinib after completion of clinical studies evaluating pirtobrutinib. The clinical studies that will feed into this master protocol are referred to as originator studies. The master protocol will govern individual study-specific appendices (ISAs) that will represent participants from the individual, completed originator studies. These participants will have the opportunity to enter this study and continue to receive treatment or continue follow-up visits. Overall, the master protocol and the individual ISAs, when combined, define the investigations for this study.

This description comes directly from the study's public registry record.

Talk to the study team

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or  ·  1-317-615-4559  ·  LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact  ·  clinical_inquiry_hub@lilly.com

Always discuss trial participation with your own doctor first.

Locations (38)

Cancer Specialists, LLCJacksonville, Florida, United StatesNot Yet Recruiting
Sylvester Comprehensive Cancer CenterMiami, Florida, United StatesRecruiting
Florida Cancer SpecialistsSarasota, Florida, United StatesRecruiting
The Emory ClinicAtlanta, Georgia, United StatesNot Yet Recruiting
Northwestern UniversityChicago, Illinois, United StatesNot Yet Recruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Mayo Clinic- MinnesotaRochester, Minnesota, United StatesRecruiting
University Of Nebraska Medical CenterOmaha, Nebraska, United StatesRecruiting
Cayuga Cancer CenterIthaca, New York, United StatesRecruiting
Northwell HealthLake Success, New York, United StatesRecruiting
Memorial Sloan-Kettering Cancer Center (MSKCC) - New YorkNew York, New York, United StatesRecruiting
Memorial Sloan-Kettering Cancer Center (MSKCC) - New YorkNew York, New York, United StatesNot Yet Recruiting

+ 26 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06876649