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Study identifier: NCT06876363 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

Condition: X-Linked Chronic Granulomatous Disease  ·  Sponsor: Ensoma

PhasePhase 1/Phase 2
Planned participants15
Who can joinMale, 3 Months to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to evaluate the safety and potential efficacy of the EN-374 treatment regimen and identify a dose level for further evaluation in participants with x-linked chronic granulomatous disease. The main questions it aims to answer are: * safety of the EN-374 treatment regimen * effect of the EN-374 treatment regimen on the production of functional neutrophils with NADPH oxidase activity

This description comes directly from the study's public registry record.

Talk to the study team

Andrew Dietz, MD, MSCR  ·  617-766-3917  ·  ddietz@ensoma.com

Always discuss trial participation with your own doctor first.

Locations (9)

University of California, Los AngelesLos Angeles, California, United StatesRecruiting
University of California, San FranciscoSan Francisco, California, United StatesRecruiting
Johns Hopkins All Children's HospitalSt. Petersburg, Florida, United StatesRecruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
University of MinnesotaMinneapolis, Minnesota, United StatesRecruiting
Columbia University Irving Medical Center, Morgan Stanley Children's HospitalNew York, New York, United StatesRecruiting
Duke UniversityDurham, North Carolina, United StatesRecruiting
University of Utah, Primary Children's HospitalSalt Lake City, Utah, United StatesRecruiting
University College London HospitalLondon, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT06876363