Condition: Luteal Support · Frozen Embryo Transfer (FET) · Sponsor: Dunamenti REK Istenhegyi IVF Center
Without progesterone there is no pregnancy. Following ovulation, the endocrine function of the follicle changes and progesterone replacing estradiol becomes its main secretory product. In the follicular phase the increasing amount of estradiol secreted by the growing follicle builds up the endometrium, while in the luteal phase progesterone, the main product of the corpus luteum, prepares the endometrium for implantation. This process is called decidualization. If implantation occurs, human chorionic gonadotropin (hCG) secreted by the trophopblasts maintains the function of the corpus luteum. This continued activity is required to be maintained up to week 7-9 of gestation when the hormone secreting activity is taken over by the placenta (luteo-placental shift) and the corpus luteum regresses. During in vitro fertilization (IVF) gonadotropins are used to induce multifollicular development and therefore following the oocyte retrieval ("ovulation") multiple corpora lutea are formed. At the same time, partly due to the supraphysiologic steroid levels reached during stimulation and partly to the removal of the granulosa cell mass during the retrieval, the activity of these corpora lutea remains insufficient and luteal support, primarily in the form of progesterone, is needed to achieve success. Embryo cryopreservation has become available soon after the first successful IVF treatment. In some of the IVF treatments cryopreservation is electively planned, while in others surplus e…
This description comes directly from the study's public registry record.
Peter Kovacs MD medical director Dunamenti REK Istenhegyi IVF Center, MD, PhD · +3612022802 · peterkovacs1970@hotmail.com
Always discuss trial participation with your own doctor first.
| Dunamenti REK Istenhegyi IVF Center | Budapest, Budapest, Hungary | Recruiting |
| Dunamenti REK Gyor IVF Center | Győr, Gyor, Hungary | Recruiting |
| University of Pecs, Dept. OBGYN, Reproductive Center | Pécs, Pecs, Hungary | Recruiting |
| University of Szeged, Reproductive Medicine Institute | Szeged, Szeged, Hungary | Recruiting |
| Dunamenti REK Tapolca IVF Center | Tapolca, Tapolca, Hungary | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06875752