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Study identifier: NCT06874868 Synced from ClinicalTrials.gov · July 28, 2026
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Salivary Cortisol As a Biomarker in Patients with Temporomandibular Disorder

Condition: Temporomandibular Joint Disorder  ·  Sponsor: University of Coimbra

PhaseN/A
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

t is recognized that cortisol, a hormone produced by the adrenal glands, is a marker that is elevated in patients with psychological disorders, particularly anxiety. On the other hand, Temporomandibular Disorders (TMD) are a condition with a multifactorial etiology, in which emotional disturbances play a crucial role. Therefore, the aim of this study is to evaluate whether patients with TMD have higher levels of salivary cortisol compared to the general population. Initially, an assessment will be conducted using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol to determine whether the patient suffer of any kind of Temporomandibular Disorder. Based on the results, individuals will be classified into two groups: the study group, consisting of patients with TMD, and the control group, composed of individuals without the disorder. Those who agree to participate will be required to sign an informed consent form. Subsequently, a saliva sample will be collected for analysis.

This description comes directly from the study's public registry record.

Talk to the study team

Bruno Macedo, PhD  ·  +351-239 249 151  ·  brunomacsousa@gmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Faculty of Medicine of University of CoimbraCoimbra, Coimbra District, PortugalRecruiting

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Source record: clinicaltrials.gov/study/NCT06874868