Condition: Liver Transplantation · Liver Diseases · Surgery · Sponsor: Charite University, Berlin, Germany
The goal of this study is to find out if quality assessment by normothermic machine perfusion can be used to safely increase the number of usable donor livers, helping more people get transplants faster and with better results. This process keeps a donated liver working outside the body before transplantation, allowing surgeons to assess whether livers previously considered unsuitable can still be used. The main questions this study aims to answer are: * Does this method help patients get a transplant sooner? * Can this method make more livers available for transplant? * Does it improve survival and health after transplant? Participants in this study must be on the waiting list for a liver transplant with a ReMELD-Na-Score of 21 or less (equivalent to MELD ≤25) and must not qualify for certain special exceptions. Participants will be randomly placed into one of two groups: * Experimental group: In addition to regular organ offers, these participants may receive a liver that was initially not considered for transplantation but meets quality standards after at least four hours of machine perfusion. * Control group: These participants will receive a liver through the usual transplant process. The main measure of success is how quickly participants receive a transplant. Researchers will also look at other important factors, such as survival rates, quality of life, hospital stay, and complications after transplant. This study may help improve liver transplantation by making …
This description comes directly from the study's public registry record.
Nathanael Raschzok, MD · +49 30 450 552 001 · nathanael.raschzok@charite.de
Simon Moosburner, MD · +49 30 450 552 595 · simon.moosburner@charite.de
Always discuss trial participation with your own doctor first.
| University Medical Center Hamburg-Eppendorf | Hamburg, Free and Hanseatic City of Hamburg, Germany | Recruiting |
| University Hospital RWTH Aachen | Aachen, North Rhine-Westphalia, Germany | Recruiting |
| University Hospital Bonn | Bonn, North Rhine-Westphalia, Germany | Recruiting |
| University Hospital Muenster | Münster, North Rhine-Westphalia, Germany | Recruiting |
| Department of Surgery Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin | Berlin, State of Berlin, Germany | Recruiting |
| Department of General, Visceral and Transplant Surgery, Hannover Medical School | Hanover, Germany | Recruiting |
| Department of General, Visceral and Transplantation Surgery, LMU University Hospital, LMU Munich | München, Germany | Recruiting |
| Department of Surgery, University Hospital Regensburg | Regensburg, Germany | Recruiting |
| Eberhard Karls University of Tübingen, Department of General Visceral and Transplant Surgery | Tübingen, Germany | Recruiting |
| Department of General, Visceral, Transplantation, Vascular, and Pediatric Surgery, University Hospital Wurzburg | Würzburg, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06874296