Condition: NAsal MEthicillin-resistant Staphylococcus · Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia
Antimicrobial resistance (AMR) is recognized as one of the major threats to global health \[1\], causing up to 25.000 deaths in the European Union every year, longer hospitalizations and increased healthcare costs. It is well known that antimicrobial use is the main driving force towards AMR and up to 50% of antimicrobial prescriptions are either inappropriate or unnecessary \[2\]. It is then important to understand how to optimize antimicrobial usage not only in adults but also in infants, as they show different resistance patterns and have peculiar characteristics that may lead to incorrect administration and alteration of the pharmacokinetic and pharmacodynamic properties of the drug \[3\]. Antimicrobials are the most prescribed drugs in children \[4\]\[5\] and this excessive usage has been recorded not only in developed countries, but also in low-income and middle-income ones \[6\]. In Europe, Italy reported one of the highest prescriptions rates, four times higher than the UK and six times higher than the Netherlands \[7\]\[8\]. 84% of Italian infants in the community have already received at least one course of antibiotics at 2 years of age \[9\]. A point-prevalence survey (PPS) showed that 38.9% of hospitalized Italian infants received at least one antibiotic prescription both for treatment and prophylaxis; in children, the most commonly used antibiotic classes were third generation cephalosporins and penicillins plus enzyme inhibitors, with a high prescription rates o…
This description comes directly from the study's public registry record.
Alessandra Ricciardi, MD · +390382501543 · a.ricciardi@smatteo.pv.it
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| Fondazione IRCCS Policlinico San Matteo, SC Malattie Infettive 1 | Pavia, Pavia, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06872099