Condition: Cognitive Disorders · Muscular Disorders, Atrophic · Sponsor: University Rovira i Virgili
Polyphenols, precisely resveratrol, with red wine as the most substantial source, was associated with improvements in cognitive function. Also, the loss of muscle mass and strength in elderly, that significantly increases dependency of these people, it could be attributed to alterations in gut microbiota through the "gut-muscle axis" and this underline the urgent need to efficiently find out any intervention or preventive approach via modulation of gut microbiota to improve muscle function in elderly. In this context, red wine polyphenols exert their effects through interaction with gut microbiota following the well-known two-way interaction between polyphenols and gut microbiota by promoting the proliferation of beneficial bacteria and increasing their abundance. Similarly, aging cognitive decline can be modulate by microbiota, notably through "gut-brain axis". Additionally, dietary polyphenols can delay inflammation or/and oxidation on the onset of age-related cognitive decline or muscular oxidation or cardiovascular factors risk factors, all of them relevant factors for the onset of physical frailty and dependence in elderly. Moreover, wine is a singular alcoholic beverage with a high content of phenolic compounds of a very diverse nature on which numerous protective effects on health have been described. In fact, wine, in addition to alcohol, contains a complex mixture of polyphenols, including anthocyanins and non-coloured phenols as proanthocyanidins, flavonols, hydrox…
This description comes directly from the study's public registry record.
Rosa Solà Alberich, Professor · +34 977 759 369 · rosa.sola@urv.cat
Anna Pedret Figuerola, Dr. · +34 977 759 375 · anna.pedret@urv.cat
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| Instituto de Ciencias de la Vid y del Vino-ICVV (Consejo Superior de Investigaciones Científicas-CSIC, Universidad de La Rioja, Gobierno de La Rioja) | Logroño, Spain, Spain | Active Not Recruiting |
| Lyfestyle, Microbiota and Health Unit, Health Sciences Faculty, University of La Rioja | Logroño, Spain, Spain | Active Not Recruiting |
| Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut) | Reus, Spain, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06871384