Condition: Neurodegenerative Diseases · Parkinson Disease · Alzheimer Disease · Sponsor: Fondazione Don Carlo Gnocchi ETS
Early diagnosis of Neurodegenerative diseases (NDDs) and accurate patient profiling are key goals needed to tailor prompt personalized therapeutic strategies that can significantly impact disease progression and patients' quality of life. The project will validate a novel, cost-effective and quick biophotonic-based method for early and differential diagnosis of NDDs (Parkinson's disease, atypical parkinsonisms, Alzheimer's disease) and for routine clinical monitoring of NDD progression (longitudinal study). Raman spectroscopy (RS) will be applied to biochemically profile saliva and salivaderived Extracellular Vesicles (sEVs) and to identify a spectroscopic biomarker for NDDs. Optimized protocols for RS will be used to concomitantly evaluate saliva and sEVs from people with NDDs and to detect salivary changes in the biochemical profile, with special focus on EV-associated components. The accuracy of the method in discriminating NDDs at different disease stages and during disease progression will be verified. A nanotechnology-based biomolecular characterization of saliva and sEV will clarify the involvement of specific pathological molecules in NDDs progression.
This description comes directly from the study's public registry record.
Pietro Arcuri, MD · +390240308833 · parcuri@dongnocchi.it
Alice Gualerzi, PhD · +390240308533 · agualerzi@dongnocchi.it
Always discuss trial participation with your own doctor first.
| IRCCS Don Gnocchi, Fondazione Don Gnocchi | Florence, FI, Italy | Recruiting |
| Azienda Ospedaliero Universitaria Careggi Firenze | Florence, Italy | Recruiting |
| IRCCS S. Maria Nascente, Fondazione Don Carlo Gnocchi ONLUS | Milan, Italy | Recruiting |
| IRCCS Istituto Neurologico "Carlo Besta" | Milan, Italy | Recruiting |
| Centro S. Maria ai Servi, Fondazione Don Carlo Gnocchi Onlus | Parma, Italy | Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06869135