● Recruiting

Study of the Link Between MASH ( Metabolic Dysfunction-Associated Steatohepatitis) and MAMs (Mitochondria-Associated Membranes ) Alteration in Patients Undergoing Bariatric Surgery - MAMBA

Condition: Metabolic Dysfunction-Associated Steatotic Liver Disease · Metabolic Dysfunction-Associated Steatohepatitis · Sleeve Gastrectomy · Sponsor: Hospices Civils de Lyon

PhaseN/A

Planned participants20

Who can joinAll sexes, 18 Years to 99 Years

Healthy volunteersNo

About this study

The main research hypothesis is that alterations in the communication between the endoplasmic reticulum (ER) and the mitochondria at contact sites called mitochondria-associated membranes (MAMs) occurs in different hepatic cell types of patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MALSD) and is involved in the progression towards MASH and could also influence the process of improvement of MASH. This study aims to investigate the link between Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Mitochondria-Associated Membranes (MAMs) in liver cells and peripheral blood mononuclear cells (PBMCs) in patients undergoing bariatric surgery. The primary objective is to analyze MAMs alterations in hepatocytes in MASH patients compared to non-MASH patients. Secondary objectives include evaluating the correlation between MAMs in PBMCs and liver cells and assessing MAMs changes post-bariatric surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Cyrielle CAUSSY, Pr · +33 4 78 86 44 48 · cyrielle.caussy@chu-lyon.fr

Always discuss trial participation with your own doctor first.

Locations (2)

Hospices Civils de Lyon - Hôpital Edouard Herriot	Lyon, France, France	Recruiting
Centre Hospitalier Lyon Sud, Endocrinologie, Diabète et nutrition	Pierre-Bénite, France, France	Recruiting

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Source record: clinicaltrials.gov/study/NCT06868992