Condition: Cirrhosis of the Liver · Alcoholic Cirrhosis · Sponsor: Copenhagen University Hospital, Hvidovre
The incidence of liver cirrhosis is increased fivefold for men and tripled for women in the last forty years. The clinical course of liver cirrhosis includes complications of ascites, hepatic encephalopathy, variceal bleeding, kidney dysfunction, and infections that markedly worsen prognosis. These complications are driven by the development of portal hypertension in the liver. This progression to the 'decompensated' stage is considered a hallmark in the disease course, as the decompensation is associated with a markedly increased risk of further complications and death. Increasing evidence indicate that active measures of treatment of the underlying cause of liver disease and removal of the toxic agents causing cirrhosis may slow disease progression or even induce regression of cirrhosis. This concept is described as hepatic recompensation. There is a need for clinical studies investigating novel biomarkers with the capability to predict and monitor improvement in alcohol related liver cirrhosis, Between 75% and 80% of patients with liver cirrhosis in Denmark have or have had a harmful use of alcohol. Alcohol related liver disease (ArLD) has a major impact on patients' health and lives, and there is an unmet need to investigate treatment options that not only relieves complications, but also address the underlying pathways of alcohol related liver disease, also in severe stages of alcohol related cirrhosis (ALC). Factors such as BMI, female gender and mild portal hyperte…
This description comes directly from the study's public registry record.
Nina Kimer, MD, PhD · +4538621968 · nina.kimer@regionh.dk
Niels P Klausen, MD · +4538621968 · niels.peter.riedel.klausen@regionh.dk
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| Copenhagen University Hospital Hvidovre | Hvidovre, Capital Region, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06866496