Condition: Acute Disseminated Encephalomyelitis · Encephalitis Autoimmune · Sponsor: University Hospital, Angers
Acute disseminated encephalomyelitis (ADEM) is a neuroinflammatory disorder of the central nervous system, manifesting itself as impaired consciousness, even to the point of coma, and multifocal neurological deficits. ADEM is the most common encephalitis in children. Moreover, 50-65% of ADEM in children is associated with the presence of anti-MOG antibodies (MOGAD). In fact, ADEM is the most frequent clinical presentation of MOGAD in children, 50-75% before the age of 10. The risk of recurrence is higher in pediatric MOGAD of ADEM manifestation, up to 30%, compared to myelitis or optic neuritis. Multiphasic MOGAD are more frequently associated with sequelae in 50-69% of cases, versus 4-32% for monophasic forms. In ADEM, cognitive and epileptic sequelae predominate. The 2020 European consortium and the 2022 national diagnosis and care protocol recommend the introduction of disease-modifying therapies as early as the second attack of the disease, or in the event of distant sequelae, in order to limit relapses and sequelae. However, these treatments take several months to take effect. There is currently no reliable predictive factor for MOGAD recurrence other than the persistence of an elevated blood anti-MOG antibody level (≥1:1280) at 1 year. The aim of this study is therefore to identify biomarkers associated with MOGAD recurrence from the first attack. To this end, we will study the transcriptome of circulating blood mononuclear cells by single-cell next-generation RNA sequ…
This description comes directly from the study's public registry record.
Nail BENALLEGUE, DOCTOR · +33241354445 · nail.benallegue@chu-angers.fr
Always discuss trial participation with your own doctor first.
| CHU d'Angers | Angers, France | Recruiting |
| Univesity Hostipal of Brest | Brest, France | Recruiting |
| Univesity Hostipal of APHP | Le Kremlin-Bicêtre, France | Recruiting |
| CHU Montpellier | Montpellier, France | Not Yet Recruiting |
| Univesity Hostipal of Nantes | Nantes, France | Recruiting |
| Hôpital Necker Enfants Malades | Paris, France | Not Yet Recruiting |
| Univesity Hostipal of Rennes | Rennes, France | Recruiting |
| Univesity Hostipal of Tours | Tours, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06863974