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Study identifier: NCT06863532 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy and Safety Comparison of Cofrogliptin Add-on Versus Metformin Dose-escalation in Type 2 Diabetes Patients Inadequately Controlled With SGLT-2 Inhibitors Plus Low-Dose Metformin:A Multicenter, Open-Label Trial

Condition: Type 2 Diabetes  ·  Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

PhaseNA
Planned participants80
Who can joinAll sexes, 18 Years to 74 Years
Healthy volunteersNo

About this study

The aim of this study is to evaluate the change in glycated hemoglobin (HbA1c) levels of adding cofrogliptin compared to escalation of metformin dose after 24 weeks in type 2 diabetes patients who have failed to achieve adequate glycemic control despite receiving combination therapy with SGLT2i and metformin. Participants will be asked to use either cofrogliptin combined with SGLT2i and metformin or SGLT2i combined with increased dose of metformin.

This description comes directly from the study's public registry record.

Talk to the study team

Wenheng Zeng, Doctor  ·  +86 137 5711 8319  ·  42590910@qq.com

Always discuss trial participation with your own doctor first.

Locations (1)

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityHangzhou, Zhejiang, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06863532