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Study identifier: NCT06863129 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial

Condition: Metastatic Bone Disease  ·  Sponsor: Michelle Ghert, MD

PhaseNA
Planned participants334
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to find out if removing and replacing part of the hip bone works better than using metal hardware to stabilize the bone in patients whose cancer has spread to the hip. The main questions are: 1. Does removing and replacing part of the bone work better than just stabilizing it with metal hardware? 2. Does removing and replacing the bone help reduce problems like cancer coming back or the metal hardware breaking? Researchers will compare two treatments: using metal rods and plates to stabilize the bone (internal fixation) versus removing part of the bone and possibly replacing the hip joint (resection and reconstruction) to see if the second option causes fewer problems. Participants will: * Be randomly assigned to one of two groups (internal fixation or resection and reconstruction). * Have one of the two surgeries based on which group they're in. * Go to follow-up appointments with the study doctor at 2 weeks, 6 weeks, 4 months, 6 months, 9 months, and 12 months after surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Olivia Virag, MA  ·  905- 521-2100  ·  viragoe@mcmaster.ca

Hadia Farrukh  ·  905- 521-2100  ·  farrukhh@mcmaster.ca

Always discuss trial participation with your own doctor first.

Locations (13)

University of Colorado HospitalAurora, Colorado, United StatesRecruiting
Parkview Packnett Family Cancer InstituteFort Wayne, Indiana, United StatesRecruiting
University of Maryland Medical CenterBaltimore, Maryland, United StatesActive Not Recruiting
Albany Medical CenterAlbany, New York, United StatesActive Not Recruiting
University of Cincinnati Medical CenterCincinnati, Ohio, United StatesRecruiting
Good Samaritan Regional Medical CenterCorvallis, Oregon, United StatesWithdrawn
Oregon Health and Science University HospitalPortland, Oregon, United StatesRecruiting
Medical University GrazGraz, AustriaRecruiting
Hospital de Clínicas de Porto AlegrePorto Alegre, Rio Grande do Sul, BrazilRecruiting
Foothills Medical CentreCalgary, Alberta, CanadaNot Yet Recruiting
Mount Sinai HospitalToronto, Ontario, CanadaActive Not Recruiting
Hôpital Maisonneuve-RosemontMontreal, Quebec, CanadaWithdrawn

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06863129