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Study identifier: NCT06859684 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Hepatic Arterial Infusion Chemotherapy (HAIC) Combined With Durvalumab and Lenvatinib in Patients With Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma: a Phase 2 Study(HAIC-quad Trial)

Condition: Intrahepatic Cholangiocarcinoma (Icc) · HAIC · Durvalumab  ·  Sponsor: West China Hospital

PhasePhase 2
Planned participants25
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

At present, the first-line treatment for patients with advanced unresectable intrahepatic cholangiocarcinoma is mainly systemic treatment, but the improvement in efficacy is limited and is not enough to meet the current clinical treatment needs. Hepatic artery infusion chemotherapy (HAIC) has the advantages of increasing local drug concentration and reducing toxic side effects compared to systemic intravenous chemotherapy. In order to enable patients with advanced intrahepatic cholangiocarcinoma to obtain better treatment effects, this study plans to explore HAIC combined with durvalumab and lenvatinib as the first-line treatment for patients with locally advanced or metastatic ICC, in order to provide a better treatment choice for their comprehensive treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Yun X Zhang, PHD  ·  18011410585  ·  zhangxiaoyun@wchscu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

West China Hospital, Sichuan UniversityChengdu, Sichuan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06859684