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Study identifier: NCT06859424 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

Condition: AML (Acute Myelogenous Leukemia) · Acute Lymphoid Leukemia (ALL) · Acute Leukemia (Category)  ·  Sponsor: Center for International Blood and Marrow Transplant Research

PhasePhase 2
Planned participants358
Who can joinAll sexes, 18 Years to 66 Years
Healthy volunteersNo

About this study

The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the study participant. The researchers will compare the new drug combination to a standard drug combination. They will also learn about the safety of each drug combination. Participants will: * Receive the standard or new drug combination after transplant * Visit the doctor's office for check-ups and tests after transplant that are routine for most transplant patients * Take surveys about physical and emotional well-being * Give blood and stool samples.

This description comes directly from the study's public registry record.

Talk to the study team

Leigh Anne Blackmon, MSW  ·  763-406-8087  ·  accelerate@nmdp.org

Always discuss trial participation with your own doctor first.

Locations (13)

University of Alabama BirminghamBirmingham, Alabama, United StatesRecruiting
City of HopeDuarte, California, United StatesRecruiting
StanfordPalo Alto, California, United StatesRecruiting
University of MiamiMiami, Florida, United StatesRecruiting
University of Kansas Medical CenterWestwood, Kansas, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Karmanos Cancer InstituteDetroit, Michigan, United StatesRecruiting
Memorial Sloan KetteringNew York, New York, United StatesRecruiting
University of North CarolinaChapel Hill, North Carolina, United StatesRecruiting
Oregon Health & Science UniversityPortland, Oregon, United StatesRecruiting
MD AndersonHouston, Texas, United StatesRecruiting
University of VirginiaCharlottesville, Virginia, United StatesRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06859424