Condition: Colorectal Neoplasms · Floxuridine · Liver Metastases · Sponsor: The Netherlands Cancer Institute
The goal of this randomized clinical trial is to investigate induction treatment with Hepatic Arterial Infusion Pump therapy combined with systemic therapy (HAIP-SYST) in chemotherapy-naive patients with unresectable colorectal liver metastases without extrahepatic disease. The main question it aims to answer is if combined HAIP-SYST improves survival compared to induction treatment with systemic therapy alone. Patients in the control arm will receive systemic therapy according to standard of care. Study procedures experimental arm * Surgery for pump placement and resection of the primary tumor * Pre- and postoperative imaging (CT-anghiography, 99mTc-MAA scintigraphy) * Induction treatment with hepatic arterial infusion pump therapy with Floxuridine combined with systemic therapy Study procedures both arms * Evaluation of resectability status by a National Liver Panel with surgeons and radiologists * Questionnaires for Quality of Life
This description comes directly from the study's public registry record.
Koert FD Kuhlmann, MD PhD · +31205129111 · pump@nki.nl
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| Antoni van Leeuwenhoek-Netherland Cancer Institute | Amsterdam, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06857773