Condition: HIV Infection · Menopause · Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Women living with HIV have been shown to experience more frequent and severe hot flashes and night sweats (collectively known as vasomotor symptoms) as compared to women living without HIV. This correlates with disturbed sleep, increased depressive symptoms, increased anxiety, worse mental function, interference with activities of daily living including work, and worse overall quality of life. Hormone therapy is considered to be the most effective therapy for hot flashes and night sweats and the most appropriate choice to prevent bone loss at the time of menopause for women without HIV. However, the usefulness of hormone therapy has not been specifically studied in women living with HIV. This trial is being done to see if: * There is evidence to support the use of hormone therapy (estradiol with or without progesterone) for the treatment of hot flashes and night sweats in women living with HIV * Hormone therapy improves mental function, mood, sleep, quality of life, bone health, heart health, and inflammation in women living with HIV * Hormone therapy is safe and tolerable for women living with HIV
This description comes directly from the study's public registry record.
ACTG ClinicalTrials.gov Coordinator · 301-628-3348 · ACTGCT.gov@dlhcorp.com
Always discuss trial participation with your own doctor first.
| 31788 Alabama CRS | Birmingham, Alabama, United States | Recruiting |
| University of California, Los Angeles CARE Center CRS (601) | Los Angeles, California, United States | Recruiting |
| UCSD Antiviral Research Center CRS (701) | San Diego, California, United States | Recruiting |
| 801 University of California, San Francisco HIV/AIDS CRS | San Francisco, California, United States | Recruiting |
| Harbor - UCLA Med. Ctr. CRS | Torrance, California, United States | Recruiting |
| University of Colorado Hospital CRS (6101) | Aurora, Colorado, United States | Recruiting |
| The Ponce de Leon Center CRS (5802) | Atlanta, Georgia, United States | Recruiting |
| Northwestern University CRS (2701) | Chicago, Illinois, United States | Recruiting |
| 201 Johns Hopkins University CRS | Baltimore, Maryland, United States | Recruiting |
| 101 Massachusetts General Hospital (MGH) CRS | Boston, Massachusetts, United States | Recruiting |
| Brigham and Women's Hosp. ACTG CRS (107) | Boston, Massachusetts, United States | Recruiting |
| 2101 Washington University Therapeutics (WT) CRS | St Louis, Missouri, United States | Recruiting |
+ 11 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06856174