Condition: CPPD - Calcium Pyrophosphate Deposition Disease · Sponsor: Brigham and Women's Hospital
The goal of this clinical trial is to learn if colchicine reduces levels of proteins indicating inflammation in the blood in individuals with calcium pyrophosphate deposition (CPPD) disease. The trial will also test the effect of colchicine on joint symptoms in CPPD disease. The main questions it aims to answer are: * Does colchicine reduce the level of interleukin 18 (IL-18) in the blood of individuals with CPPD disease? * Does colchicine reduce pain scores in individuals with CPPD disease? Researchers will compare colchicine once daily to a placebo (a look-alike pill that contains no drug) to see if colchicine works to treat CPPD disease. Participants will: * Take colchicine or a placebo every day for 6 months * Visit the clinic 3 times in 6 months for joint examinations, surveys, and blood tests. Each visit will last 2-3 hours. * Speak on the telephone with researchers for about 4 times over 6 months. Each phone call will last about 5 minutes.
This description comes directly from the study's public registry record.
Brenna Sharp de Flores, Senior Research Coordinator · 617-732-6277 · bsharp@bwh.harvard.edu
Sara Tedeschi, MD, MPH · stedeschi1@bwh.harvard.edu
Always discuss trial participation with your own doctor first.
| University of Alabama - Birmingham | Birmingham, Alabama, United States | Recruiting |
| University of California - Los Angeles | Los Angeles, California, United States | Recruiting |
| Boston University Medical Center/Boston Medical Center | Boston, Massachusetts, United States | Recruiting |
| Brigham and Women's Hospital | Boston, Massachusetts, United States | Recruiting |
| Medical College of Wisconsin | Milwaukee, Wisconsin, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06855433