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Study identifier: NCT06855277 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

Condition: Prostate Cancer  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants940
Who can joinMale, 18 Years to 100 Years
Healthy volunteersNo

About this study

The purpose of this study is to determine whether \[225Ac\]Ac-PSMA-617 (AAA817), given for up to 6 cycles at a dose of 10 Megabecquerel (MBq) +/- 10%, plus androgen receptor pathway inhibitor (ARPI), improves the radiographic progression free survival (rPFS) compared to investigator's choice of standard of care (SOC) (ARPI change or taxane-based chemotherapy or \[177Lu\]Lu-PSMA-617 (AAA617)) in adult participants with PSMA-positive metastatic castration resistant prostate cancer (mCRPC) treated with another ARPI as last treatment and who have not been exposed to a taxane-containing chemotherapy in the mCRPC setting nor have received any prior PSMA-targeting radioligand therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111

Always discuss trial participation with your own doctor first.

Locations (88)

Urology Centers Of Alabama PcHomewood, Alabama, United StatesRecruiting
Stanford University Medical CenterPalo Alto, California, United StatesRecruiting
Sansum ClinicSanta Barbara, California, United StatesRecruiting
Rocky Mountain Cancer CentersDenver, Colorado, United StatesRecruiting
Florida Cancer SpecialistsFort Myers, Florida, United StatesRecruiting
Baptist Health SouthMiami, Florida, United StatesRecruiting
AdventHealthOrlando, Florida, United StatesRecruiting
University Cancer and Blood Center LLCAthens, Georgia, United StatesRecruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
Univ Of Iowa Hospitals And ClinicsIowa City, Iowa, United StatesRecruiting
University of Kansas HospitalKansas City, Kansas, United StatesRecruiting
East Jefferson HospitalMetairie, Louisiana, United StatesRecruiting

+ 76 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06855277