Condition: Neonatal Resuscitation · Apnea Neonatal · Sponsor: Michelle Baczynski
Many extremely premature infants require immediate help with breathing after birth. Positive pressure ventilation (PPV) using a device called a T-piece resuscitator is a common method. PPV is needed to establish proper lung function, improve gas exchange, and encourage the infant to breathe spontaneously. However, T-piece resuscitators have limitations, like a lack of visual feedback and variable settings, which may result in reduced effectiveness of PPV. Improving PPV effectiveness may reduce the need for more invasive procedures, such as intubation, which pose an increased risk of complications and death for these fragile infants. A novel approach, that may overcome the above limitations and deliver PPV with precise settings through a nasal mask, is to use a ventilator to deliver PPV (V-PPV) using a respiratory mode called nasal intermittent positive pressure ventilation (NIPPV). While NIPPV is commonly used in neonatal intensive care units to support breathing in premature infants, the impact of V-PPV use during immediate post-birth stabilization needs to be studied. Preliminary data from our recent single-center study confirmed the feasibility of using V-PPV for resuscitation of extremely premature babies and indicated its potential superiority with a 28% decrease in the need for intubation compared to historical use of T-piece. This promising innovation may enhance outcomes for these vulnerable infants by refining the way we provide respiratory support in their critical …
This description comes directly from the study's public registry record.
Thaiani Wulff, BSc · 1-416-586-4800. · thaiani.wulff@sinaihealth.ca
Laura Thomas, MSc · 416-586-4800 · laura.thomas@sinaihealth.ca
Always discuss trial participation with your own doctor first.
| Cedars-Sinai Guerin Children's | Los Angeles, California, United States | Recruiting |
| Foothills Medical Centre | Calgary, Alberta, Canada | Recruiting |
| Royal Alexandra Hospital | Edmonton, Alberta, Canada | Recruiting |
| BC Children's and Women's Hospital | Vancouver, British Columbia, Canada | Not Yet Recruiting |
| McMaster Children's Hospital | Hamilton, Ontario, Canada | Recruiting |
| Children's Hospital at London Health Sciences Centre | London, Ontario, Canada | Not Yet Recruiting |
| Mount Sinai Hospital | Toronto, Ontario, Canada | Recruiting |
| Montreal Children's Hospital | Montral, Quebec, Canada | Recruiting |
| CHU Sainte Justine | Montreal, Quebec, Canada | Recruiting |
| Rigshospitalet Coppenhagen | Copenhagen, Denmark | Not Yet Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06849596