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Study identifier: NCT06846762 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

DREAM Study: DNA/RNA-NGS Co-Testing in Driver-Negative, Treatment-Resistant NSCLC

Condition: Non-Small Cell Lung Cancer  ·  Sponsor: Baohui Han

PhaseN/A
Planned participants508
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

The study is divided into two parts, Part A and Part B. The purpose of Part A is to reveal the proportion of NSCLC patients who are primarily resistant to first-line non-targeted therapy due to the omission of driver genes (especially fusion variations) by DNA-NGS, the median PFS of patients in the first line, and clinical characteristics through synchronous co-testing of DNA and RNA NGS. The purpose of Part B is to compare the difference in ORR between patients with driver gene positivity identified through synchronous co-testing of DNA and RNA NGS who receive and do not receive targeted therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Yuqing Lou  ·  13917197711  ·  louyq@hotmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Shanghai Chest HospitalShanghai, Shanghai Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06846762