Condition: Pancreatic Cancer · Sponsor: Shandong Cancer Hospital and Institute
This study aims to evaluate the safety and efficacy of Ivonescimab, a bispecific antibody targeting PD-1 and VEGF, in combination with stereotactic body radiotherapy (SBRT) and chemotherapy for treating locally advanced pancreatic cancer (LAPC). The Phase Ib portion is a dose-escalation study to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and the recommended Phase II dose (RP2D) of Ivonescimab. The Phase II portion will assess the median progression-free survival (mPFS) of patients receiving Ivonescimab with SBRT (25-50Gy/5F) and modified FOLFIRINOX chemotherapy. The study aims to provide critical insights into treatment options for LAPC and inform future therapeutic strategies.
This description comes directly from the study's public registry record.
Jinbo Yue, Doctor · 0531-67626442 · jbyue@sdfmu.edu.cn
Always discuss trial participation with your own doctor first.
| Shandong Cancer Hospital and Institute | Jinan, Shandong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06844422