Condition: Locally Advanced Esophageal Squamous Cell Carcinoma · Sponsor: Nanfang Hospital, Southern Medical University
This was a single-center, open phase II clinical study. 34 patients with resectable local middle and advanced esophageal squamous cell carcinoma were treated with anti-PD-1 antibody combined with sequential chemoratherapy regimen: Phase I:Toripalimab (240mg day1, Q3W\*2cycle) + clinical routine chemotherapy regimen selected by the investigator; The second stage: Toripalimab (240mg day1, Q3W\*1cycle) + radiotherapy (intensity modulated radiotherapy, 40Gy/20F, 2Gy/F); Surgery was performed 4-6 weeks after completion, and subsequent treatment options were considered after surgery according to MDT discussion. According to the postoperative pathological results, the pathological complete response (pCR) and major response (MPR) were evaluated. The disease-free survival (DFS), overall survival (OS), 1 or 2 years survival rate and adverse reactions were recorded.
This description comes directly from the study's public registry record.
Wei Wang · 020-61642135 · 29262574@qq.com
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| Nanfang Hospital, Southern Medical University | Guangzhou, Baiyun District, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06843889