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Study identifier: NCT06841354 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Condition: Triple Negative Breast Neoplasms  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants1000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers want to know if sacituzumab tirumotecan given alone or with pembrolizumab can treat triple negative breast cancer (TNBC). The main goal of this study is to learn if people treated with sacituzumab tirumotecan alone or with pembrolizumab live longer overall or without the cancer growing or spreading compared to people treated with chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (267)

USA Mitchell Cancer Institute ( Site 0090)Mobile, Alabama, United StatesRecruiting
Ironwood Cancer & Research Centers ( Site 0036)Chandler, Arizona, United StatesRecruiting
City of Hope ( Site 0097)Duarte, California, United StatesRecruiting
City of Hope Lennar Foundation Cancer Center ( Site 0099)Irvine, California, United StatesRecruiting
UCLA Department of Medicine - Hematology & Oncology ( Site 0047)Los Angeles, California, United StatesRecruiting
UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0016)San Francisco, California, United StatesRecruiting
Yale New Haven Hospital ( Site 0001)New Haven, Connecticut, United StatesCompleted
Washington Hospital Center ( Site 0098)Washington D.C., District of Columbia, United StatesRecruiting
AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0007)Altamonte Springs, Florida, United StatesRecruiting
Orlando Health Cancer Institute ( Site 0012)Orlando, Florida, United StatesRecruiting
Florida Cancer Specialists - East ( Site 7000)West Palm Beach, Florida, United StatesRecruiting
University Cancer & Blood Center, LLC ( Site 0023)Athens, Georgia, United StatesRecruiting

+ 255 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06841354