Condition: Advanced Solid Tumors · Ovarian Cancer · Endometrial Cancer · Sponsor: Pheast Therapeutics
This is a multi-center, first-in-human (FIH), open-label, Phase 1a/1b dose escalation and dose expansion study to assess the safety, PK, pharmacodynamics, and antitumor activity of PHST001 monotherapy (Phase 1a) or in combination with chemotherapy (Phase 1b) in adult participants with advanced relapsed and/or refractory solid tumors (including but not limited to CNS tumors in Phase 1a only). In Phase 1b cohort expansions, the study will focus on participants with advanced relapsed and/or refractory ovarian cancer, endometrial cancer, and cholangiocarcinoma. The study's primary objective is to evaluate the safety and tolerability of PHST001 and determine the RP2D (Recommended Phase 2 dose) of PHST001 monotherapy and in combination with chemotherapy as well as assess the anti-tumor activity of PHST001 and chemotherapy in Phase 1b.
This description comes directly from the study's public registry record.
Andrew Ferguson/VP Clinical Development, PhD · 434-249-2349 · medical@pheast.com
Always discuss trial participation with your own doctor first.
| Precision NextGen Oncology & Research Center | Beverly Hills, California, United States | Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles, California, United States | Recruiting |
| Stanford University School of Medicine | Palo Alto, California, United States | Recruiting |
| Sarah Cannon Research Institute (SCRI) Oncology Partners - Denver Health One | Denver, Colorado, United States | Recruiting |
| Yale Cancer Center | New Haven, Connecticut, United States | Recruiting |
| University of Chicago Medical Center | Chicago, Illinois, United States | Recruiting |
| Dana Farber Cancer Institute | Boston, Massachusetts, United States | Recruiting |
| University of Michigan Rogel Cancer Center | Ann Arbor, Michigan, United States | Recruiting |
| START Center for Cancer Research - Midwest | Grand Rapids, Michigan, United States | Recruiting |
| START Center for Cancer Research - Long Island New York | Lake Success, New York, United States | Recruiting |
| Mount Sinai | New York, New York, United States | Recruiting |
| Duke Cancer Institute | Durham, North Carolina, United States | Recruiting |
+ 8 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06840886