Condition: SLE · Systemic Lupus Erythematosus (SLE) · CAR T Cell · Sponsor: Children's Hospital of Philadelphia
This is a single-center, single-arm, open-label phase 1/2 study of CART19 in children and young adults with refractory Systemic lupus erythematosus (SLE), including both patients diagnosed with lupus nephritis (LN) and patients with non-renal Systemic lupus erythematosus (SLE). Phase 1 will evaluate the safety of CART19 in 6-12 patients with Systemic lupus erythematosus (SLE). There is no planned dose escalation, but a dose de-escalation will be made based on the incidence of Dose Limiting Toxicities. Phase 2 will evaluate the efficacy and further evaluate the safety of CART19 in this population.
This description comes directly from the study's public registry record.
Caitlin Elgarten, MD · 267-425-7964 · elgartenc@chop.edu
Melissa Varghese · 845-553-5358 · verghesem@chop.edu
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| Children's Hospital of Philadelphia | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06839976