Condition: Rectal Cancer, Radiotherapy · Anal Pain · Acute Radiation Dermatitis · Sponsor: Qianfoshan Hospital
Background: According to GLOBOCAN 2022 statistics, colorectal cancer has become the third most common cancer disease worldwide, and also the second leading cause of death. The incidence rate of rectal cancer is particularly prominent. Radiotherapy is one of the important methods for comprehensive treatment of rectal cancer, but the radiation damage caused by radiotherapy cannot be ignored. During radiotherapy for rectal cancer, the skin of the anal canal will be damaged by radiation, resulting in acute radiation dermatitis, which is characterized by redness, pain, and ulcers. The main symptom of patients is anal pain. As the radiation dose accumulates, the skin damage to the anal canal becomes increasingly severe, and the patient's anal pain becomes more severe, which seriously affects the patient's quality of life. Mepilex Lite Dressings can absorb the exudate, keep it moist, promote the healing of radioactive dermatitis, and relieve pain. However, when inserting into the anal canal, the patient reported significant pain that was difficult to tolerate. Therefore, indomethacin suppositories were administered rectally before inserting the dressing, which has been proven to have a reliable analgesic effect by research. In summary, the main objective of this study is to determine the effectiveness of Mepilex Lite Dressings combined with indomethacin suppositories in the treatment of acute radiation dermatitis of anal canal skin in patients with rectal cancer undergoing radiother…
This description comes directly from the study's public registry record.
Heli Shang, undergraduate · +8613789820123 · 1197@sdhospital.com.cn
Yanwei Yang, postgraduate · +8615863788372 · 15863788372@163.com
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| The First Affiliated Hospital of Shandong First Medical University | Jinan, Shandong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06837831