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Study identifier: NCT06835556 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy

Condition: Schizophrenia Disorders  ·  Sponsor: Vanderbilt University Medical Center

PhaseNA
Planned participants120
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders. The main questions are: 1. do prior expectations about environmental volatility reduce following effective psychotherapeutic treatment of delusions? 2. does corresponding brain activity related to volatility change with effective treatment of delusions? Participants will: 1. engage in CBTp or TAU + phone check-ins for 16 weeks 2. complete assessments at 4 timepoints over the course of 6 months 3. complete an MRI when possible

This description comes directly from the study's public registry record.

Talk to the study team

Julia Sheffield, PhD  ·  615-343-3839  ·  julia.sheffield@vumc.org

Always discuss trial participation with your own doctor first.

Locations (1)

Vanderbilt University Medical CenterNashville, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06835556