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Study identifier: NCT06835530 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Combination of Rituximab and CC-99282 as Front-line Therapy for Older Frail Patients With Diffuse Large B-cells Non-Hodgkin Lymphoma Evaluated With a Simplified Geriatric Assessment (sGA): a Phase II Study of the Fondazione Italiana Linfomi (FIL)

Condition: Diffuse Large B Cell Non-Hodgkin Lymphoma  ·  Sponsor: Fondazione Italiana Linfomi - ETS

PhasePhase 2
Planned participants47
Who can joinAll sexes, 80 Years to no upper limit
Healthy volunteersNo

About this study

Prospective, multicenter, single arm, phase II study, to evaluate the efficacy of the combination rituximab-golcadomide as a chemo free approach in a population of older patients with new diagnosis of DLBCL, defined as frail according to a sGA evaluation and not candidate for the standard R-CHOP (or R-CHOP like) treatments.

This description comes directly from the study's public registry record.

Talk to the study team

Uffici Studi FIL  ·  +390131033153  ·  startup@filinf.it

Uffici Studi FIL  ·  +390599769913  ·  gestionestudi@filinf.it

Always discuss trial participation with your own doctor first.

Locations (20)

AOU SS. Antonio e Biagio e Cesare Arrigo di Alessandria - SCDU EmatologiaAlessandria, ItalyRecruiting
AOU Ospedali Riuniti - Clinica di EmatologiaAncona, ItalyRecruiting
Azienda Ospedaliera S. Giuseppe Moscati - S.C. Ematologia e trapianto emopoieticoAvellino, ItalyRecruiting
Ospedale IRCCS Centro di Riferimento Oncologico di Aviano - Divisione di Oncologia e dei Tumori immuno-correlatiAviano, ItalyRecruiting
ASST Spedali Civili di Brescia - EmatologiaBrescia, ItalyRecruiting
Azienda Ospedaliera Universitaria Careggi -Unità Funzionale di EmatologiaFlorence, ItalyRecruiting
ASST Grande Ospedale Metropolitano Niguarda - SC EmatologiaMilan, ItalyRecruiting
Fondazione IRCCS San Gerardo dei Tintori -EmatologiaMonza, ItalyRecruiting
I.R.C.C.S. Istituto Oncologico Veneto -Oncologia 1Padova, ItalyRecruiting
Policlinico Giaccone - EmatologiaPalermo, ItalyNot Yet Recruiting
Azienda Sanitaria Locale di Pescara- Presidio Ospedaliero Santo Spirito - U.O.C. EmatologiaPescara, ItalyNot Yet Recruiting
Azienda USL Piacenza - UOC Ematologia e Centro Trapianti,Piacenza, ItalyRecruiting

+ 8 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06835530