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Study identifier: NCT06835049 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma (TNT-HYPE)

Condition: Sarcoma,Soft Tissue  ·  Sponsor: Swiss Cancer Institute

PhasePhase 2
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Soft tissue sarcomas (STSs) are rare cancers with a 5-year survival rate of 60%, and there is no standard treatment for high-risk extremity and trunk STSs (eSTS). A phase III trial suggests that adding moderate regional hyperthermia (HT) to anthracycline-based chemotherapy, followed by surgery and radiotherapy (RT), can improve 10-year overall survival by 10%. This trial aims to optimize treatment by combining the most effective regimens from chemotherapy, HT, RT, and surgery, and will evaluate the feasibility of this new total neoadjuvant treatment (TNT) approach.

This description comes directly from the study's public registry record.

Talk to the study team

Gwendoline Wicki  ·  +41 31 389 91 91  ·  trials@sakk.ch

Always discuss trial participation with your own doctor first.

Locations (8)

Kantonsspital AarauAarau, SwitzerlandRecruiting
Universitaetsspital BaselBasel, SwitzerlandRecruiting
EOC - Istituto Oncologico della Svizzera ItalianaBellinzona, SwitzerlandRecruiting
Inselspital Bern - Universitätsklinik für RadioonkologieBern, SwitzerlandRecruiting
CHUV - Swiss Cancer Center LausanneLausanne, SwitzerlandRecruiting
hoch Health Ostschweiz - Kantonsspital St. GallenSankt Gallen, SwitzerlandRecruiting
Kantonsspital WinterthurWinterthur, SwitzerlandRecruiting
Universitätsspital ZürichZurich, SwitzerlandRecruiting

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Source record: clinicaltrials.gov/study/NCT06835049