Condition: Trauma; Complications · Sponsor: Hospices Civils de Lyon
Acute Kidney Injury (AKI) occurs in 24% of trauma patients, and is even more common in those with severe trauma. It is a major contributor to morbidity and mortality in trauma. Diagnosis of AKI is based on elevated serum creatinine and decreased urine output, two functional markers already indicating the presence of a significant kidney function impairment. Earlier detection of kidney stress, at a preclinical stage when cellular modifications are still reversible, could reduce the occurrence of AKI episodes if nephroprotective measures are rapidly implemented. Several randomized controlled trials have shown that early implementation of such a nephroprotection bundle-of-care in patients at risk of AKI after major surgery reduces the incidence of severe AKI within 72 hours. Although its use is supported by international guidelines, this nephroprotection bundle-of-care is rarely implemented in its totality, due to the significant financial and human resources required for its full implementation. The Nephrocheck® (NC) test is a urine test for which a result \> 0.3 is predictive of AKI development. It might enable early identification of trauma patients at risk of AKI, so that implementation of the nephroprotection bundle-of-care could be targeted solely at those high-risk patients. Thus, the investigators hypothesize that in a population of severe trauma patients (ISS score\>15) at risk of AKI (defined by a NC on Intensive Care Unit (ICU) admission \> 0.3), early implementati…
This description comes directly from the study's public registry record.
Céline MONARD · 04 72 11 13 27 · celine.monard@chu-lyon.fr
Karine POYAU · 04 72 11 53 81 · karine.poyau@chu-lyon.fr
Always discuss trial participation with your own doctor first.
| Centre Hospitalier universitaire Estaing, Service anesthésie-réanimation | Clermont-Ferrand, France | Not Yet Recruiting |
| Centre hospitaler Annecy Genevois, Service de réanimation | Épagny, France | Not Yet Recruiting |
| Centre hospitalier universitaire de Grenoble Alpes, Pôle anesthésie-réanimation | La Tronche, France | Not Yet Recruiting |
| Hospices Civils de Lyon, Hôpital Edouard Herriot, Service d'anesthésie-réanimation | Lyon, France | Recruiting |
| Hospices Civils de Lyon, Hôpital Lyon-Sud, Service d'anesthésie-réanimation | Pierre-Bénite, France | Recruiting |
| Centre hospitalier universitaire de Saint Etienne, Hôpital Bellevue, Service anesthésie-réanimation | Saint-Etienne, France | Not Yet Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06834633