Condition: Heart Failure With Preserved Ejection Fraction · Atrial Fibrillation, Persistent · Sponsor: French Cardiology Society
The goal of this clinical trial is to assess the clinical efficacy of physiological pacing combined with atrioventricular node ablation, in patients with Heart Failure with preserved Ejection Fraction (HFpEF) and well controlled permanent atrial fibrillation.The main question it aims to answer is that heart rate regularization added to physiological pacing - preventing the deleterious effect of right ventricular apical pacing - would reduce mortality and heart failure hospitalizations. Researchers will compare physiological pacing combined with atrioventricular node ablation (intervention arm) versus optimal pharmacological therapy (control arm) to see if physiological pacing combined with atrioventricular node ablation reduce time to the composite of all-cause mortality or hospitalization due to heart failure or intravenous diuretics (time frame 24 months). Participants will : * Be randomized in intervention arm or control arm. * Visit the clinic 3 months, 12 months and 24 months after the randomization for checkups and tests.
This description comes directly from the study's public registry record.
Tessa BERGOT, MSc · +33144907033 · tessa.bergot@sfcardio.fr
Always discuss trial participation with your own doctor first.
| OLV Aalst | Aalst, Belgium | Not Yet Recruiting |
| UZ Leuven | Leuven, Belgium | Not Yet Recruiting |
| Clinique St Pierre Ottignies | Ottignies-Louvain-la-Neuve, Belgium | Not Yet Recruiting |
| CHRU de Brest - Hôpital de la Cavale Blanche | Brest, France | Not Yet Recruiting |
| CHRU de Caen | Caen, France | Not Yet Recruiting |
| CHRU de Tours - Trousseau | Chambray-lès-Tours, France | Not Yet Recruiting |
| CHU Grenoble Alpes | Grenoble, France | Not Yet Recruiting |
| Groupe Hospitalier La Rochelle-Ré-Aunis | La Rochelle, France | Not Yet Recruiting |
| CHRU Lille | Lille, France | Not Yet Recruiting |
| GHICL Allome - Hôpital St Philibert | Lomme, France | Not Yet Recruiting |
| Clinique Millenaire | Montpellier, France | Not Yet Recruiting |
| CHU de Nantes - Hôpital Nord Laennec | Nantes, France | Not Yet Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06833138