Condition: Adrenal Cortical Carcinoma · Adrenal Cortical Cancer · Adrenal Cancer · Sponsor: West China Hospital
Adrenocortical carcinoma (ACC) is a rare aggressive malignant tumor. According to the literature, the 5-year survival rate of ACC is 12%-47%. For patients with advanced ACC, mitotane alone or combined with traditional chemotherapy was the first-line standard treatment, but its progression-free survival was only about 1 year. The efficacy of mitotane monotherapy is approximately 10% to 30%. FIRM-ACT trial reported an objective response rate (ORR) of 23.2% for etoposide, doxorubicin, cisplatin, and mitotane (EDP-M) chemotherapy regimen. Our phase II study found that PD-1 inhibitor camrelizumab and apatinib showed impressive clinical data in the second-line treatment of relapsed and metastatic ACC patients. The aim of this study is to evaluate the efficacy and safety of PD-1 inhibitor camrelizumab combined with apatinib and mitotane in advanced ACC, and to explore a new treatment strategy for patients with advanced ACC.
This description comes directly from the study's public registry record.
Xingchen Peng, PhD · +86 18980606753 · pxx2014@scu.edu.cn
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| West China Hospital | Chengdu, Sichuan, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06831175