Condition: Primary Central Nervous System Lymphoma · Sponsor: University Hospital Freiburg
Most patients being diagnosed with primary diffuse large B-cell lymphoma of the central nervous system (PCNSL) are 60 years or older. Elderly patients with PCNSL have a poor prognosis and there is a great medical need to improve outcome for this vulnerable population. In Germany and many international centres, there are currently two widely used strategies to treat elderly PCNSL patients who are eligible for high-dose methotrexate (HD-MTX) treatment, which have not yet been compared head-to-head. The R-MP regimen has been established by the Cooperative PCNSL Study Group as a "conventional" immunochemotherapy standard treatment for elderly patients with newly diagnosed disease and consists of Rituximab, HD-MTX and Procarbazine followed by maintenance therapy with Procarbazine. In contrast, another recently established protocol also includes HD-MTX-based induction therapy, but followed by consolidating high-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT). This is an overall more intensive, but substantially shorter treatment approach, feasible for elderly patients being considered eligible for a more intensive treatment. The PRIMA-CNS trial aims to compare these two treatment approaches with respect to survival, response rates and toxicity.
This description comes directly from the study's public registry record.
Elisabeth Schorb, MD · +49 761 270-35360 · elisabeth.schorb@uniklinik-freiburg.de
Gerald Illerhaus, MD · +49 711 278-30400 · g.illerhaus@klinikum-stuttgart.de
Always discuss trial participation with your own doctor first.
| University Hospital Freiburg, Department Medicine I, Hematology, oncology and stem cell transplantation | Freiburg im Breisgau, Baden-Wurttemberg, Germany | Recruiting |
| Klinikum Stuttgart, Clinic of Hematology, Oncology and Palliative Care, Stuttgart Cancer Center / Tumor Center Eva Mayr-Stihl | Stuttgart, Baden-Wurttemberg, Germany | Recruiting |
| University Hospital Aachen | Aachen, Germany | Recruiting |
| University Hospital Augsburg | Augsburg, Germany | Recruiting |
| Helios Klinikum Berlin-Buch | Berlin, Germany | Not Yet Recruiting |
| University Hospital Berlin | Berlin, Germany | Recruiting |
| Evangelisches Klinikum Bethel | Bielefeld, Germany | Not Yet Recruiting |
| Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH | Bochum, Germany | Recruiting |
| Städtisches Klinikum Braunschweig gGmbH | Braunschweig, Germany | Recruiting |
| Klinikum Bremen-Mitte gGmbH | Bremen, Germany | Recruiting |
| Klinikum Chemnitz gGmbH | Chemnitz, Germany | Not Yet Recruiting |
| Universitätsklinikum Köln | Cologne, Germany | Not Yet Recruiting |
+ 23 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06830421