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Study identifier: NCT06830200 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Peri-implantitis Treatment With Chitosan Brush

Condition: Peri-implantitis  ·  Sponsor: Hacettepe University

PhaseNA
Planned participants60
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

In dentistry, dental implant applications for tooth loss/deficiency are prominent and provide successful long-term results in terms of functionality and aesthetics. However, peri-implant diseases such as peri-implant mucositis and peri-implantitis may develop due to biofilm accumulation around the implant. In peri-implantitis, in addition to the clinical inflammation findings seen in peri-implant mucositis, there is also progressive bone loss. This condition is to be treated with non-surgical or surgical methods. Titanium curettes, ultrasonic instruments, laser systems, and chitosan brushes are used for biofilm removal in non-surgical treatment. Chitosan is a natural polysaccharide obtained from chitin. It is biocompatible, biodegradable, and has antibacterial activity. In addition, chitosan reduces the levels of IL-1β, IL-6, and TNF-α, which also play a role in the pathogenesis of peri-implantitis, and exhibits anti-inflammatory effects on macrophages activated by lipopolysaccharide. Although many methods are used to treat peri-implantitis, successful and predictable results cannot be obtained. This study aims to examine the clinical and immunological findings and observe the changes in the non-surgical treatment of peri-implantitis using chitosan brush or titanium curette over 12 months. Sixty dental implants diagnosed with peri-implantitis clinically and radiographically at the Department of Periodontics, Faculty of Dentistry, Hacettepe University will be included in the s…

This description comes directly from the study's public registry record.

Talk to the study team

Buket Acar, PHD  ·  +90 312 305 2217  ·  dtbuketacar@gmail.com

Always discuss trial participation with your own doctor first.

Locations (1)

Hacettepe UniversityAnkara, Turkey (Türkiye)Recruiting

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Source record: clinicaltrials.gov/study/NCT06830200