Condition: Infection · Cancer · Rejection · Sponsor: Hospices Civils de Lyon
Long-term outcomes in kidney transplantation remain a significant challenge, as complications such as donor-specific antibodies (DSA), antibody-mediated rejection, infections, and cancer increasingly threaten graft and patient survival over time. The development of non-invasive biomarkers to guide the management of therapeutic immunosuppression beyond the first year post-transplantation is therefore a crucial unmet need. Torque Teno Virus (TTV), a non-pathogenic virus with a high prevalence worldwide, has emerged as a promising biomarker in this context. Its replication inversely reflects immune control by T cells, correlating with the depth of therapeutic immunosuppression. Additionally, its slow replication kinetics make TTV DNAemia a useful marker for evaluating patient adherence to immunosuppressive treatments. The TAOIST study tests whether longitudinal monitoring of TTV DNAemia every six months, starting from the second year after transplantation, can guide the personalization of immunosuppressive therapy. The primary endpoint is the time to the first occurrence of complications linked to inadequate immunosuppression, including dnDSA, biopsy-proven rejection, infection, cancer, or graft loss. Secondary objectives include evaluating the acceptability of TTV DNAemia among healthcare professionals and assessing its cost-effectiveness compared to standard care. An ancillary objective examines the link between TTV DNAemia and the immunosuppressant possession ratio (IPR) to…
This description comes directly from the study's public registry record.
Olivier THAUNAT, Professor MD, PhD · +334.72.11.69.28 · olivier.thaunat@chu-lyon.fr
Always discuss trial participation with your own doctor first.
| Service de Néphrologie-Transplantation-Dialyse I Hôpital Pellegrin I - CHU Bordeaux | Bordeaux (France), France | Not Yet Recruiting |
| Service de transplantation, néphrologie et immunologie clinique Hospices Civils de Lyon, Hôpital Edouard Herriot | Lyon, France | Recruiting |
| Service de Néphrologie, Dialyse et Transplantation Rénale Nouvel Hôpital Civil | Strasbourg (france), France | Not Yet Recruiting |
| Département de Néphrologie et Transplantation d'Organes Hôpital Rangueil - CHU de Toulouse | Toulouse (France), France | Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06829719