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Study identifier: NCT06829238 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use

Condition: Systemic Inflammation · Immune Dysregulation · Injection Drug Use  ·  Sponsor: University of Alabama at Birmingham

PhasePhase 4
Planned participants100
Who can joinAll sexes, 18 Years to 64 Years
Healthy volunteersNo

About this study

This randomized clinical trial (RCT) evaluates whether metformin can reduce systemic inflammation and improve immune function in individuals with a history of injection drug use, with or without HIV. Participants will receive metformin or placebo and undergo immune system assessments, including vaccine response evaluations.

This description comes directly from the study's public registry record.

Talk to the study team

Ellen Eaton, MD, MSPH  ·  205-975-0661  ·  eeaton@uabmc.edu

James Kobie, PhD  ·  205-934-8800  ·  jjkobie@uabmc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Alabama at BirminghamBirmingham, Alabama, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06829238