Condition: Diffuse Large B-Cell Lymphoma (DLBCL) · Sponsor: Danielle Wallace
Older patients with diffuse large B- cell lymphoma (DLBCL) do not have the same rates of disease control as younger patients and are at risk for toxicity. Identifying which patients might benefit from more therapy at the end of first-line treatment is important. The ability to measure small amounts of persistent lymphoma (circulating tumor DNA or ctDNA) might allow the investigators to risk stratify patients. If older patients have detectable ctDNA in the blood at the end of six cycles of polatuzumab vedotin, rituximab and dose-attentuated CHP chemotherapy, patients will receive a bispecific antibody called mosunetuzumab. The investigators hypothesize this will result in "clearing" the ctDNA from the blood and result in better disease control and outcomes for patients. The study will also measure the safety of this regimen and the impact on the function of these older patients utilizing a tool called the geriatric assessment.
This description comes directly from the study's public registry record.
Danielle Wallace, MD · 585-273-5761 · danielle_wallace@urmc.rochester.edu
Clinical Trials Office · wcictoresearch@urmc.rochester.edu
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| Wilmot Cancer Institute | Rochester, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06828991