Condition: Naevi · Neurodevelopmental Disorder · Congenital Nevus · Sponsor: Nantes University Hospital
Congenital Nevus (CN) is a pigmented skin lesion present at birth, which grows in size as the child grows. It can vary in appearance and is classified by its size, from small (less than 1.5 cm) to giant (greater than 40 cm). CN is associated with genetic mutations, mainly in the NRAS/BRAF genes. A large CN can lead to several clinical issues, including: Risk of neurological disorders: Large CN can be associated with neurological abnormalities such as neuro-meningeal melanosis, hydrocephalus, or brain malformations. These conditions may cause early neuro-developmental delays. The risk is not well understood and requires further studies. Risk of melanoma: The risk of developing melanoma is higher for a large CN but remains low for smaller ones. Increased monitoring is necessary during the early years for large and giant CN. Psycho-social impact: Parents often experience significant anxiety at birth due to the cancer risk and social stigma. As the child grows, a visible CN may impact their quality of life, particularly socially at school. Management of CN remains controversial, especially for those of medium to giant size or with multiple satellites. There is an urgent need for further research to clarify best practices in monitoring and treatment, including the need for routine brain imaging and criteria for surgical intervention. Ultimately, this study aims to deepen our understanding of CN, its associated neurological and melanoma risks, and the psycho-social challenges…
This description comes directly from the study's public registry record.
Research and Innovation Department of Nantes UH · +33253482810 · bp-prom-regl@chu-nantes.fr
Hélène AUBERT, M.D. · Helene.AUBERT@chu-nantes.fr
Always discuss trial participation with your own doctor first.
| Grasse Hospital | Nice, Alpes-Maritimes, France | Not Yet Recruiting |
| Nice University Hospital and Lenval Hospital | Nice, Alpes-Maritimes, France | Not Yet Recruiting |
| Marseille University Hospital | Marseille, Bouches-du-Rhône, France | Not Yet Recruiting |
| Dijon University Hospital | Dijon, Côte-d'Or, France | Not Yet Recruiting |
| La Réunion University Hospital | La Réunion, Département Et Région d'Outre-mer, France | Not Yet Recruiting |
| Brest University Hospital | Brest, Finistère, France | Not Yet Recruiting |
| Bordeaux University Hospital | Bordeaux, Gironde, France | Not Yet Recruiting |
| Toulouse University Hospital | Toulouse, Haute-Garonne, France | Not Yet Recruiting |
| Rennes University Hospital | Rennes, Ille-et-Vilaine, France | Not Yet Recruiting |
| Tours University Hospital | Tours, Indre-et-Loire, France | Not Yet Recruiting |
| Nantes University Hospital | Nantes, Loire Atlantique, France | Recruiting |
| Angers University Hospital | Angers, Maine et Loire, France | Not Yet Recruiting |
+ 4 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06828822