Condition: Locally Advanced Breast Cancer · Unresectable Breast Carcinoma · Metastatic Breast Cancer · Sponsor: BioNTech SE
This is a Phase I/II, multi-site, open-label, two-part study designed to evaluate the efficacy, safety, optimized dose and contribution of components of BNT323 (also known as trastuzumab pamirtecan and DB-1303) in combination with BNT327 (also known as pumitamig and PM8002) in participants with hormone receptor-positive (HR+) or hormone receptor-negative (HR-), Human epidermal growth factor receptor (HER)2-positive, HER2-low (immunohistochemistry \[IHC\] 1+ or IHC 2+/in situ hybridization -), HER2-ultralow (IHC 0, with membrane staining) or HER2-null breast cancer (BC), or triple-negative breast cancer (TNBC).
This description comes directly from the study's public registry record.
BioNTech clinical trials patient information · +49 6131 9084 · patients@biontech.de
Always discuss trial participation with your own doctor first.
| Beverly Hills Cancer Center | Beverly Hills, California, United States | Recruiting |
| Hoag Memorial Hospital Presbyterian | Newport Beach, California, United States | Recruiting |
| Hematology - Oncology Associates of the Treasure Coast | Port Saint Lucie, Florida, United States | Recruiting |
| University Cancer & Blood Center, LLC | Athens, Georgia, United States | Recruiting |
| Winship Cancer Institute of Emory University | Atlanta, Georgia, United States | Recruiting |
| University of Illinois Hospital & Health Sciences System | Chicago, Illinois, United States | Recruiting |
| Brigitte Harris Cancer Pavilion BHCP | Detroit, Michigan, United States | Recruiting |
| START Midwest, LLC | Grand Rapids, Michigan, United States | Recruiting |
| Saint Luke's Hospital of Kansas City | Kansas City, Missouri, United States | Recruiting |
| Washington University School of Medicine | St Louis, Missouri, United States | Recruiting |
| Memorial Sloan Kettering Cancer Center Basking Ridge | Basking Ridge, New Jersey, United States | Recruiting |
| Summit Medical Group | Florham Park, New Jersey, United States | Recruiting |
+ 56 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06827236