Condition: Insomnia · Sponsor: Woolcock Institute of Medical Research
The goal of this clinical trial is to explore the potential neuroprotective benefits of a dual orexin receptor antagonist (DORA) in adults with insomnia. The main questions it aims to answer are: * Does the DORA reduce blood-based phosphorylated TAU181, in adults with insomnia, when compared to placebo * Does the DORA reduce other blood-based biomarkers of neurodegeneration, including phosphorylated TAU217, amyloid beta 40:42 ratio, Neurofilament Light Chain (NFL) and Glial Fibrillary Acidic Protein (GFAP), when compared to placebo. Participants will: * Take 10mg Lemborexant nightly for two weeks * Take a matching placebo nightly for two weeks * Visit the research institute for a screening visit and for an overnight visit at the conclusion of each study drug treatment (3 visits in total).
This description comes directly from the study's public registry record.
Camilla Hoyos, MPH, PhD · 0438801044 · camilla.hoyos@mq.edu.au
Rhearne Ryan, HScHons, PhD · +61 2 9805 3274 · rhearne.ryan@woolcock.org.au
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| Woolcock Institute of Medical Research | Macquarie Park, New South Wales, Australia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06823752