Condition: HCC · Sponsor: Chinese University of Hong Kong
Patients with PVTT involvement is a significant healthcare burden as they are present in up to 40% of patients with HCC at diagnosis. These patients exhibit a poorer prognosis compared to patients without PVTT, as a result they were often excluded from existing pivotal clinical trials \[9-11\]. Without management, the median OS in affected patients could be as short as 2 to 4 months. The role of liver-directed therapies is limited for patients with major PVTT. For example, percutaneous ablation to PVTT is technically challenging, especially for centrally located PVTT due to their proximity to hepatic vasculature and bile ducts. Transarterial therapies are contraindicated for patients with major PVTT due to risk of concurrent interruption of both hepatic arterial and portal venous blood flow resulting in severe liver ischemia. Therefore, patients with major PVTT are recommended to receive systemic treatment by international guidelines. Yet, the OS for patients with main PVTT remained poor. In the exploratory analysis of IMbrave-150, patients with main PVTT who received atezolizumab plus bevacizumab had a median OS of 7.6 months only, compared to 21.1 months for those without PVTT. There is a huge unmet for this group of patients with dismal prognosis. SBRT is a radiotherapy technique that enables delivery of high dose of radiation in an extremely precise manner. Compared to more conventional radiotherapy techniques such as intensity modulated radiotherapy (IMRT), SBRT has the…
This description comes directly from the study's public registry record.
Landon CHAN · 3505 1042 · landon.chan@cuhk.edu.hk
Natalie KWONG · 3505 1040 · nataliekwong019@cuhk.edu.hk
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| Department of Clinical Oncology, Prince of Wales Hospital | Hong Kong, Hong Kong | Recruiting |
| Department of Clinical Oncology, Tuen Mun Hospital | Hong Kong, Hong Kong | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06823375