Condition: Coronary Artery Disease · Sponsor: University of Florida
Dual antiplatelet therapy (DAPT) with low-dose aspirin and a P2Y12 inhibitor is the current standard of care in patients with coronary artery disease experiencing an acute event or undergoing percutaneous coronary intervention. However, the ischemic benefits are counterbalanced by a significant increase in bleeding events. Over time, different DAPT de-escalation strategies have been developed to reduce the bleeding risk while maintaining the ischemic protection, but there is currently no head-to-head comparison between them. The purpose of this clinical trial is to conduct a head-to-head comparison on the pharmacodynamic efficacy of DAPT de-escalation by dose reduction to low-dose prasugrel (5 mg od) and DAPT de-escation by switching from standard-dose more potent P2Y12 receptor inhibitor to standard-dose clopidogrel (75 mg). To determine if the PD profiles of these two strategies are comparable, we aim to conduct a non-inferiority study.
This description comes directly from the study's public registry record.
Luis Ortega, MD, PhD · 904-244 2060 · Luis.Ortega@jax.ufl.edu
Andrea Burton, MPH, CCRP · 904-244-5617 · Andrea.Burton@jax.ufl.edu
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| University of Florida | Jacksonville, Florida, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06821191